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| Friday, December 1st , 2045 |
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| Wisconsin Timber Rattlers: Signed Manager Devin Vainer. |
| Thursday, November 30th , 2045 |
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| Dayton Dragons: Fired Pitching Coach Kane Holbrooks. |
| Lakewood BlueClaws: Signed Manager Marcos Gomez. |
| Saturday, November 25th , 2045 |
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| Lansing Lugnuts: Activated RP Trevor Kelley from the injured list. |
| Lansing Lugnuts: Activated 1B Justin Geiger from the injured list. |
| Wisconsin Timber Rattlers: Activated SP Guillermo Delgado from the injured list. |
| Wisconsin Timber Rattlers: Activated RP Brian Heimerman from the injured list. |
| Charleston RiverDogs: Activated RP George Grady from the injured list. |
| Charleston RiverDogs: Activated RP Mike Stewart from the injured list. |
| Lake County Captains: Activated SP Eduardo Garcia from the injured list. |
| Cedar Rapids Kernels: Activated RP Justin Nourse from the injured list. |
| Hagerstown Suns: Activated CL Gilberto Ricalde from the injured list. |
| Friday, November 10th , 2045 |
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| Hartford Yard Goats: 2B Guillermo Veronese retired from professional baseball. |
| Lakewood BlueClaws: RP Ricardo Dominguez retired from professional baseball. |
| Hickory Crawdads: 1B Brian Morrison retired from professional baseball. |
| Delmarva Shorebirds: RP Salvatore Molina retired from professional baseball. |
| Kannapolis Intimidators: RP Takao Saito retired from professional baseball. |
| Beloit Snappers: RF Jonathan McDaniel retired from professional baseball. |
| Kannapolis Intimidators: SS Harvey Harvey retired from professional baseball. |
| Beloit Snappers: CF Juan Villafana retired from professional baseball. |
| Greensboro Grasshoppers: SS Humberto Oros retired from professional baseball. |
| Clinton LumberKings: SS Emmanuel Thomas retired from professional baseball. |
| Beloit Snappers: 3B Kyle Waters retired from professional baseball. |
| Lakewood BlueClaws: Manager Ryan Newman retires. |
| Saturday, November 4th , 2045 |
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| Kannapolis Intimidators: 1B Tony Arenas retired from professional baseball. |
| 1B Steve Olenski retired from professional baseball. |
| SP Bryan Whetstine retired from professional baseball. |
| RP Danny Ellis retired from professional baseball. |
| Kannapolis Intimidators: 1B Mike Brickey retired from professional baseball. |
| CL Paul Ellsworth retired from professional baseball. |
| CL Troy Chapman retired from professional baseball. |
| Kannapolis Intimidators: RF Justin Starnes retired from professional baseball. |
| RP Marcos Murcia retired from professional baseball. |
| SS Bobby Light retired from professional baseball. |
| C Danny Juarez retired from professional baseball. |
| RP Wibawa Simbolon retired from professional baseball. |
| 2B Jose Copado retired from professional baseball. |
| RP Mark McDonald retired from professional baseball. |
| SP Gustavo Palacios retired from professional baseball. |
| RF Jesus Marquez retired from professional baseball. |
| 3B Luis Trinidad retired from professional baseball. |
| 1B Shi-xian Juan retired from professional baseball. |
| RP Jason Gunn retired from professional baseball. |
| RP Kanne Krebbers retired from professional baseball. |
| RP Daniel Kaefer retired from professional baseball. |
| RP Daniel Sullivan retired from professional baseball. |
| SP Lawrence Luning retired from professional baseball. |
| LF Bill Tardiff retired from professional baseball. |
| Wisconsin Timber Rattlers: Manager Mauro Gomez retires. |
| Pitching Coach Corey Madden retires. |
| Hitting Coach Josh Labandeira retires. |
| Manager Joseph Ayers retires. |
| Hitting Coach Tom King retires. |
| Manager Kenny Holmberg retires. |
| Pitching Coach Bill Murphy retires. |
| Hitting Coach Oliver Wakefield retires. |
| Hitting Coach Justin Nutter retires. |
| Manager Adam Cooper retires. |
| Pitching Coach Morgan Woodham retires. |
| Hitting Coach Isaiah Toney retires. |
| Manager Mark Ellis retires. |
| Pitching Coach Chris Richardson retires. |
| Lexington Legends: Pitching Coach Logan Harrelson leaves the team, his contract was not renewed |
| Cedar Rapids Kernels: Manager Tom Bartlett leaves the team, his contract was not renewed |
| Quad Cities River Bandits: Pitching Coach Devin Vainer leaves the team, his contract was not renewed |
| Quad Cities River Bandits: Hitting Coach Daz Cameron leaves the team, his contract was not renewed |
| Greensboro Grasshoppers: Hitting Coach Marcos Gomez leaves the team, his contract was not renewed |
| Binghamton Mets: Manager Eric Krebs leaves the team, his contract was not renewed |
| Lakewood BlueClaws: Hitting Coach Jamie Johnson leaves the team, his contract was not renewed |
| Lakewood BlueClaws: Pitching Coach Ryan O'Shea leaves the team, his contract was not renewed |
| Hagerstown Suns: Hitting Coach Jonathan Clark leaves the team, his contract was not renewed |
| Kane County Cougars: Pitching Coach Elias Hernandez leaves the team, his contract was not renewed |
| Wednesday, October 25th , 2045 |
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| Lansing Lugnuts: Placed RP Dylan Batstone on the active roster. |
| Lansing Lugnuts: Activated RP Dylan Batstone from the injured list. |
| Saturday, October 14th , 2045 |
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| Lansing Lugnuts: Placed 1B Justin Geiger on the 7-day injured list, retroactive to 10/11/2045. |
| Monday, August 28th , 2045 |
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| Lakewood BlueClaws: Signed Manager Ryan Newman. |
| Sunday, August 27th , 2045 |
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| Lansing Lugnuts: Placed RP Doug Axelsen on the active roster. |
| Lansing Lugnuts: Activated RP Doug Axelsen from the injured list. |
| Lansing Lugnuts: Placed RP Danny Cervantes on the active roster. |
| Lansing Lugnuts: Activated RP Danny Cervantes from the injured list. |
| Lansing Lugnuts: Placed RP Dylan Batstone on the 7-day injured list, retroactive to 08/24/2045. |
| Lansing Lugnuts: Placed RP Trevor Kelley on the 7-day injured list, retroactive to 08/24/2045. |
| Monday, August 21st , 2045 |
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| Kannapolis Intimidators: Signed -name %name to a %number-year contract extension. |
| Sunday, August 13th , 2045 |
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| Lansing Lugnuts: Placed 2B Kennet Strijbis on the active roster. |
| Lansing Lugnuts: Activated 2B Kennet Strijbis from the injured list. |
| Lansing Lugnuts: Placed RP Danny Cervantes on the 7-day injured list, retroactive to 08/10/2045. |
| Lansing Lugnuts: Released 1B Carlos Ramirez. |
| Sunday, July 30th , 2045 |
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| Lansing Lugnuts: Placed RP Doug Axelsen on the 7-day injured list, retroactive to 07/27/2045. |
| Lansing Lugnuts: Placed 2B Kennet Strijbis on the 7-day injured list, retroactive to 07/27/2045. |
| Monday, July 10th , 2045 |
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| Quad Cities River Bandits: Signed -name %name to a %number-year contract extension. |
| Sunday, June 11th , 2045 |
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| Delmarva Shorebirds: Activated RP David Burrus from the injured list. |
| Hagerstown Suns: Activated RP Chris Doty from the injured list. |
| Hagerstown Suns: Placed SP Jonathan Arce on the 7-day injured list, retroactive to 06/08/2045. |
| Hagerstown Suns: Placed SP Chris Bonham on the 7-day injured list, retroactive to 06/09/2045. |
| Monday, May 8th , 2045 |
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| Hickory Crawdads: SP Tim Honaker was designated for assignment. |
| Sunday, April 16th , 2045 |
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| Lansing Lugnuts: Placed 2B Tristan Dennis on the 7-day injured list, retroactive to 04/15/2045. |
| Sunday, April 9th , 2045 |
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| Kannapolis Intimidators: Released 1B Claudio Kamminga. |
| Kannapolis Intimidators: Released 1B Mike Brickey. |
| Kannapolis Intimidators: Released 1B Steve Olenski. |
| Kannapolis Intimidators: Released 1B Ray Walden. |
| Kannapolis Intimidators: Released 1B Tony Arenas. |
| Kannapolis Intimidators: Released RF Tony Saenz. |
| Kannapolis Intimidators: Released RF Nick Massengale. |
| Kannapolis Intimidators: Released RF Danny Bunn. |
| Kannapolis Intimidators: Released RF Justin Starnes. |
| Saturday, April 1st , 2045 |
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| West Michigan Whitecaps: Placed SP Cory Weinert on the 7-day injured list, retroactive to 03/29/2045. |
| Wednesday, January 25th , 2045 |
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| Lake County Captains: Signed Manager Billy Dilley. |
