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| Tuesday, December 27th , 2050 |
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| Dayton Dragons: Signed Manager Giancarlo Stanton. |
| Friday, November 25th , 2050 |
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| Hickory Crawdads: RP George Rubio becomes a free-agent. |
| Atlanta (MID) Braves: RP Tim Kull becomes a free-agent. |
| Sunday, November 13th , 2050 |
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| Bowling Green Hot Rods: Signed Manager Tim Connell. |
| Saturday, November 12th , 2050 |
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| Quad Cities River Bandits: Signed Manager Gustavo Pierre. |
| Wednesday, November 9th , 2050 |
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| Lansing Lugnuts: Placed RF Kurt Estep on the active roster. |
| Lansing Lugnuts: Activated RF Kurt Estep from the injured list. |
| Lansing Lugnuts: Appointed Javier Baez as Manager. |
| Tuesday, November 8th , 2050 |
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| Greensboro Grasshoppers: RP Jesus Gomez retired from professional baseball. |
| Hartford Yard Goats: CF Tyler Allen retired from professional baseball. |
| Binghamton Mets: SP Ethan Massey retired from professional baseball. |
| Charleston RiverDogs: 3B Tadaaki Kondo retired from professional baseball. |
| Hagerstown Suns: C Chris Rosinsky retired from professional baseball. |
| West Virginia Power: RF Joe Vida retired from professional baseball. |
| Hagerstown Suns: 2B Phil Lomax retired from professional baseball. |
| Kane County Cougars: CF Jeff Trapp retired from professional baseball. |
| Charleston RiverDogs: RP Greg Ritchie retired from professional baseball. |
| Binghamton Mets: Pitching Coach Adam Kolarek retires. |
| Greensboro Grasshoppers: Pitching Coach Chris Marlowe retires. |
| Quad Cities River Bandits: Pitching Coach George Brown retires. |
| Thursday, November 3rd , 2050 |
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| SP Mario Arce retired from professional baseball. |
| Beloit Snappers: RP Andy Silveira retired from professional baseball. |
| SP Warren Swan retired from professional baseball. |
| 2B Kevin Wiles retired from professional baseball. |
| RP Alberto Castillo retired from professional baseball. |
| SP Jose Montoya retired from professional baseball. |
| Beloit Snappers: RP Alfonso Alvarado retired from professional baseball. |
| RP David Murcia retired from professional baseball. |
| RP Hugo Aquino retired from professional baseball. |
| SP Sam Wood retired from professional baseball. |
| RF John Holst retired from professional baseball. |
| C Johnny Burroughs retired from professional baseball. |
| SP Dan Marino IV retired from professional baseball. |
| RP David Arnold retired from professional baseball. |
| 3B Ryan Clark retired from professional baseball. |
| RP Cameron Williams retired from professional baseball. |
| 1B Dan Thomey retired from professional baseball. |
| 2B Ryan Bush retired from professional baseball. |
| RP Alec Guglielmo retired from professional baseball. |
| 2B Dan Burkhart retired from professional baseball. |
| LF Adonis Jenifer retired from professional baseball. |
| RP Eddie Aguirre retired from professional baseball. |
| RF Jose Jimenez retired from professional baseball. |
| CF Benoît Morin retired from professional baseball. |
| 1B Ruben Luis retired from professional baseball. |
| RF Jose Cabello retired from professional baseball. |
| RP Josh Armstrong retired from professional baseball. |
| Quad Cities River Bandits: 3B John Moore retired from professional baseball. |
| 1B Tae-geun Kwang retired from professional baseball. |
| RF Vaclav Been retired from professional baseball. |
| 1B Taki Matsui retired from professional baseball. |
| Quad Cities River Bandits: C Tom Bemis retired from professional baseball. |
| RF Alex Melgoza retired from professional baseball. |
| RP Paul Griffin retired from professional baseball. |
| Quad Cities River Bandits: Hitting Coach Brian Nicholson retires. |
| Hitting Coach Shawn Roof retires. |
| Hitting Coach Jeff Salazar retires. |
| Hitting Coach Kevin Mahoney retires. |
| Pitching Coach Chris Hatcher retires. |
| Manager Brandon Fowler retires. |
| Pitching Coach Jose Vega retires. |
| Manager Juan Nicasio retires. |
| Pitching Coach Arquimedes Caminero retires. |
| Delmarva Shorebirds: Hitting Coach Byron Buxton leaves the team, his contract was not renewed |
| Bowling Green Hot Rods: Manager Richard Hauser leaves the team, his contract was not renewed |
| Kannapolis Intimidators: Manager Nathan Eikhoff leaves the team, his contract was not renewed |
| Cedar Rapids Kernels: Manager Alex Garcia leaves the team, his contract was not renewed |
| Cedar Rapids Kernels: Hitting Coach Matt Thaiss leaves the team, his contract was not renewed |
| West Virginia Power: Manager Cruz Gomez leaves the team, his contract was not renewed |
| Thursday, September 29th , 2050 |
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| Lansing Lugnuts: Placed 3B Lao-che Zhu on the active roster. |
| Lansing Lugnuts: Activated 3B Lao-che Zhu from the injured list. |
| Lansing Lugnuts: Placed RF Kurt Estep on the 7-day injured list, retroactive to 09/26/2050. |
| Thursday, September 15th , 2050 |
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| Lansing Lugnuts: Released 3B Javier Garcia. |
| Sunday, August 28th , 2050 |
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| Lansing Lugnuts: Placed LF Adam O'Hare on the active roster. |
| Lansing Lugnuts: Activated LF Adam O'Hare from the injured list. |
| Tuesday, August 16th , 2050 |
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| Dayton Dragons: Signed -name %name to a %number-year contract extension. |
| Sunday, August 14th , 2050 |
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| Lansing Lugnuts: Placed SS Jeff Long on the active roster. |
| Lansing Lugnuts: Activated SS Jeff Long from the injured list. |
| Sunday, August 7th , 2050 |
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| Lansing Lugnuts: Placed SS Jeff Long on the 7-day injured list, retroactive to 08/06/2050. |
| Lansing Lugnuts: Placed RF Kurt Estep on the active roster. |
| Lansing Lugnuts: Activated RF Kurt Estep from the injured list. |
| Friday, July 29th , 2050 |
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| Lansing Lugnuts: Placed 3B Lao-che Zhu on the active roster. |
| Lansing Lugnuts: Activated 3B Lao-che Zhu from the injured list. |
| Friday, July 22nd , 2050 |
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| Lansing Lugnuts: Placed LF Luis Gomez on the 7-day injured list, retroactive to 07/21/2050. |
| Lansing Lugnuts: Placed RF Kurt Estep on the 7-day injured list, retroactive to 07/19/2050. |
| Lansing Lugnuts: Placed 3B Lao-che Zhu on the 7-day injured list, retroactive to 07/21/2050. |
| Sunday, July 10th , 2050 |
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| Quad Cities River Bandits: Signed -name %name to a %number-year contract extension. |
| Friday, July 1st , 2050 |
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| Lansing Lugnuts: Placed SP Jesse Fields on the active roster. |
| Lansing Lugnuts: Activated SP Jesse Fields from the injured list. |
| Friday, May 20th , 2050 |
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| Lansing Lugnuts: Placed SP John Murray on the 7-day injured list, retroactive to 05/17/2050. |
| Friday, May 13th , 2050 |
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| Great Lakes Loons: Activated SP Zach Clausen from the injured list. |
| Friday, May 6th , 2050 |
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| Lansing Lugnuts: Placed LF Luis Gomez on the 7-day injured list, retroactive to 05/03/2050. |
| Lansing Lugnuts: Placed SP Gil Brady on the 7-day injured list, retroactive to 05/03/2050. |
| Fort Wayne TinCaps: Appointed Itsuo Yoshioka as Manager. |
| Fort Wayne TinCaps: Appointed Jeremiah Watts as Hitting Coach. |
| Sunday, April 17th , 2050 |
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| Quad Cities River Bandits: Signed Manager Virgil Laverick. |
| Friday, April 8th , 2050 |
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| Lansing Lugnuts: Placed LF Luis Gomez on the 7-day injured list, retroactive to 04/07/2050. |
| Friday, April 1st , 2050 |
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| Great Lakes Loons: Placed RP Luis Diaz on the 7-day injured list, retroactive to 03/29/2050. |
| Thursday, February 24th , 2050 |
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| West Michigan Whitecaps: Signed Manager George Pinkard. |
