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| Friday, December 8th , 2045 |
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| Columbus Clippers: Signed Manager Khalil Fobbs. |
| Sunday, November 26th , 2045 |
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| Norfolk Tides: SP Ben Knapp becomes a free-agent. |
| Durham Bulls: 1B Ian Sousa becomes a free-agent. |
| Buffalo Bisons: DH Jesus Romero becomes a free-agent. |
| Salt Lake Bees: RF Vinny Carreno becomes a free-agent. |
| Round Rock Express: 2B Zhi-bin Ou-yang becomes a free-agent. |
| Round Rock Express: C Alvare Bairro becomes a free-agent. |
| New Orleans Zephyrs: SP Alex Mora becomes a free-agent. |
| New Orleans Zephyrs: 2B Tommy Hughes becomes a free-agent. |
| New Orleans Zephyrs: CF Luis Aguilar becomes a free-agent. |
| Louisville Bats: 3B Reilly Hawkins becomes a free-agent. |
| Albuquerque Isotopes: SS Jason Gee becomes a free-agent. |
| Reno Aces: LF Joe Smack becomes a free-agent. |
| Reno Aces: 1B Mario Soto becomes a free-agent. |
| Reno Aces: RF Chris Escobar becomes a free-agent. |
| Saturday, November 25th , 2045 |
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| Scranton WB RailRiders: Activated RP Ricardo Villar from the injured list. |
| Scranton WB RailRiders: Activated SP Greg Adair from the injured list. |
| Rochester Red Wings: Activated SP Frank Whitemore from the injured list. |
| Rochester Red Wings: Activated RP Hiromasa Kumasaka from the injured list. |
| Thursday, November 9th , 2045 |
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| Indianapolis Indians: Signed Manager Reiver Sanmartin. |
| Wednesday, November 8th , 2045 |
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| Memphis Redbirds: Signed Manager Jose Bautista. |
| Saturday, November 4th , 2045 |
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| Louisville Bats: SP Graciano Caramelo retired from professional baseball. |
| Gwinnett Braves: RP Tony Ramirez retired from professional baseball. |
| Charlotte Knights: LF Omar Lopez retired from professional baseball. |
| Scranton WB RailRiders: C Luis Balderas retired from professional baseball. |
| Columbus Clippers: 2B Jonathan DeFranco retired from professional baseball. |
| Charlotte Knights: RF Anthony Howie retired from professional baseball. |
| Iowa Cubs: Pitching Coach Jayson Ruhlman retires. |
| Columbus Clippers: Pitching Coach Carlos Bohorquez retires. |
| Memphis Redbirds: Manager Matt Macri retires. |
| Norfolk Tides: Pitching Coach Edgar Osuna leaves the team, his contract was not renewed |
| Pawtucket Red Sox: Pitching Coach Kian Riley leaves the team, his contract was not renewed |
| Fresno Grizzlies: Hitting Coach Jose Sotillo leaves the team, his contract was not renewed |
| Lehigh Valley IronPigs: Hitting Coach Fernando Encarnacion leaves the team, his contract was not renewed |
| Lehigh Valley IronPigs: Pitching Coach Carlos Leon leaves the team, his contract was not renewed |
| Oklahoma City Dodgers: Hitting Coach Felix Munoz leaves the team, his contract was not renewed |
| Sacramento River Cats: Pitching Coach Moises Hernandez leaves the team, his contract was not renewed |
| Monday, October 30th , 2045 |
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| Colorado Springs Sky Sox: 3B Roberto Castaneda retired from professional baseball. |
| El Paso Chihuahuas: 1B Chris Haugen retired from professional baseball. |
| New Orleans Zephyrs: LF Omar Contreras retired from professional baseball. |
| Norfolk Tides: SP Jason Fishman retired from professional baseball. |
| Albuquerque Isotopes: LF Nate Carrell retired from professional baseball. |
| New Orleans Zephyrs: SS J.J. Barajas retired from professional baseball. |
| New Orleans Zephyrs: LF Jesus Castillo retired from professional baseball. |
| Charlotte Knights: RF Rafael Cruz retired from professional baseball. |
| Tacoma Rainiers: LF Sumiki Ryu retired from professional baseball. |
| Gwinnett Braves: SP Jon Solorzano retired from professional baseball. |
| Tacoma Rainiers: LF Ismael Bello retired from professional baseball. |
| Durham Bulls: Hitting Coach Matt Berezay retires. |
| Columbus Clippers: Manager Yunir Garcia retires. |
| Wednesday, October 25th , 2045 |
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| Buffalo Bisons: Placed 2B Pedro Nin on the active roster. |
| Buffalo Bisons: Activated 2B Pedro Nin from the injured list. |
| Sunday, October 22nd , 2045 |
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| Syracuse Chiefs: Signed -name %name to a %number-year contract extension. |
| Sunday, September 24th , 2045 |
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| Charlotte Knights: Placed SP Takahide Watanabe on the active roster. |
| Charlotte Knights: Activated SP Takahide Watanabe from the injured list. |
| Friday, September 1st , 2045 |
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| Colorado Springs Sky Sox: Placed RP Nate Dallman on the active roster. |
| Colorado Springs Sky Sox: Activated RP Nate Dallman from the injured list. |
| Friday, August 25th , 2045 |
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| Toledo Mud Hens: 1B Chris Wheatley was designated for assignment. |
| Monday, August 21st , 2045 |
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| Columbus Clippers: SP Matt Laverty was designated for assignment. |
| Sunday, July 30th , 2045 |
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| Buffalo Bisons: Placed CF Cody Schumacher on the 7-day injured list, retroactive to 07/29/2045. |
| Friday, June 16th , 2045 |
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| Omaha Storm Chasers: 3B Gareth Busby was designated for assignment. |
| Omaha Storm Chasers: LF Zion Davidson was designated for assignment. |
| Sunday, June 11th , 2045 |
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| Colorado Springs Sky Sox: Placed RP Nate Dallman on the 7-day injured list, retroactive to 06/08/2045. |
| Colorado Springs Sky Sox: Placed SP Carlos Delgado on the active roster. |
| Colorado Springs Sky Sox: Activated SP Carlos Delgado from the injured list. |
| Norfolk Tides: Placed LF Mario Saez on the 7-day injured list, retroactive to 06/10/2045. |
| Syracuse Chiefs: Placed SS Jim Towle on the 7-day injured list, retroactive to 06/08/2045. |
| Syracuse Chiefs: Placed C Brennan Cameron on the 7-day injured list, retroactive to 06/09/2045. |
| Friday, June 9th , 2045 |
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| Round Rock Express: 1B David Simpson was designated for assignment. |
| Sunday, May 28th , 2045 |
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| Charlotte Knights: Received RP Joel Campbell from ML Chicago for injury rehab. |
| Monday, May 22nd , 2045 |
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| Oklahoma City Dodgers: SP Phil Feldscher was designated for assignment. |
| Sunday, May 21st , 2045 |
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| Buffalo Bisons: Placed RP Luis Bautista on the 7-day injured list, retroactive to 05/20/2045. |
| Buffalo Bisons: Placed CF Danny Burnside on the 7-day injured list, retroactive to 05/18/2045. |
| Sunday, May 7th , 2045 |
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| Buffalo Bisons: Placed CF Danny Burnside on the active roster. |
| Buffalo Bisons: Activated CF Danny Burnside from the injured list. |
| Buffalo Bisons: Placed SP Spencer Jones on the active roster. |
| Buffalo Bisons: Activated SP Spencer Jones from the injured list. |
| Sunday, April 30th , 2045 |
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| Colorado Springs Sky Sox: Placed SP Carlos Delgado on the 7-day injured list, retroactive to 04/27/2045. |
| Sunday, April 23rd , 2045 |
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| Buffalo Bisons: Placed 3B Danny Heyer on the active roster. |
| Buffalo Bisons: Activated 3B Danny Heyer from the injured list. |
| Buffalo Bisons: Placed CF Francisco Hernandez on the 7-day injured list, retroactive to 04/20/2045. |
| Sunday, April 16th , 2045 |
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| Buffalo Bisons: Placed 3B Danny Heyer on the 7-day injured list, retroactive to 04/13/2045. |
| Sunday, April 9th , 2045 |
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| Charlotte Knights: Released 2B Mark Cholagh. |
| Charlotte Knights: Released LF Omar Lopez. |
| Charlotte Knights: Released RF Victor Ferrermena. |
| Charlotte Knights: Released LF Anthony Howie. |
| Saturday, April 1st , 2045 |
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| Oklahoma City Dodgers: Placed SP Russell Rider on the 7-day injured list, retroactive to 03/29/2045. |
| Oklahoma City Dodgers: Placed 2B Roger Simmons on the 7-day injured list, retroactive to 03/29/2045. |
| Friday, March 31st , 2045 |
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| Buffalo Bisons: Appointed Lucas Giolito as Pitching Coach. |
| Buffalo Bisons: Appointed Andrew Yerzy as Hitting Coach. |
| Tuesday, March 7th , 2045 |
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| Charlotte Knights: Appointed Kris Hall as Pitching Coach. |
| Wednesday, February 15th , 2045 |
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| Durham Bulls: Signed Manager Jonathan Barratt. |
