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| Monday, December 11th , 2045 |
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| Chattanooga Lookouts: Signed Manager Will Skinner. |
| Friday, December 1st , 2045 |
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| San Jose Giants: Signed Manager Chris Haugen. |
| Monday, November 27th , 2045 |
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| Midland RockHounds: Signed Manager Jonathan Clark. |
| Saturday, November 25th , 2045 |
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| Erie SeaWolves: Activated RP Cory Weinert from the injured list. |
| Monday, November 6th , 2045 |
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| Reading Fightin Phils: Signed Manager Mike McGuire. |
| Saturday, November 4th , 2045 |
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| Mississippi Braves: RP Tom Lessor retired from professional baseball. |
| Corpus Christi Hooks: 1B Joe Cook retired from professional baseball. |
| Birmingham Barons: RF Victor Lema retired from professional baseball. |
| Harrisburg Senators: Hitting Coach Sixto Ortega retires. |
| Bowie Baysox: Hitting Coach Travis Snider leaves the team, his contract was not renewed |
| Trenton Thunder: Pitching Coach Jason Kiley leaves the team, his contract was not renewed |
| Erie SeaWolves: Hitting Coach Michael Marshall leaves the team, his contract was not renewed |
| Northwest Arkansas Naturals: Pitching Coach Carson Cross leaves the team, his contract was not renewed |
| Chattanooga Lookouts: Manager Josh Griess leaves the team, his contract was not renewed |
| Chattanooga Lookouts: Pitching Coach Kevin Magee leaves the team, his contract was not renewed |
| Arkansas Travelers: Pitching Coach Dan Jennings leaves the team, his contract was not renewed |
| Corpus Christi Hooks: Pitching Coach Dakota Donovan leaves the team, his contract was not renewed |
| Corpus Christi Hooks: Hitting Coach Michael Fitzgerald leaves the team, his contract was not renewed |
| Columbia Fireflies: Manager Ozzie Lewis leaves the team, his contract was not renewed |
| Reading Fightin Phils: Pitching Coach Todd Redmond leaves the team, his contract was not renewed |
| Reading Fightin Phils: Manager Adam Heidenfelder leaves the team, his contract was not renewed |
| San Jose Giants: Manager Jorge Piedra leaves the team, his contract was not renewed |
| Thursday, November 2nd , 2045 |
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| Mobile BayBears: Signed -name %name to a %number-year contract extension. |
| Sunday, October 29th , 2045 |
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| Tulsa Drillers: SP Greg Weislo retired from professional baseball. |
| Pensacola Blue Wahoos: SP Miguel Estrada retired from professional baseball. |
| Colorado (EL) Rockies: 2B John Rodd retired from professional baseball. |
| Jacksonville Suns: RF Gustavo Patella retired from professional baseball. |
| Jacksonville Suns: 1B Shelby Peddle retired from professional baseball. |
| Altoona Curve: RF Pedro Criollo retired from professional baseball. |
| Colorado (EL) Rockies: RP Waldemar van der Sluijs retired from professional baseball. |
| Columbia Fireflies: RP Stan Pitcher retired from professional baseball. |
| Midland RockHounds: Manager J.D. Martin retires. |
| Sunday, July 16th , 2045 |
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| New Hampshire Fisher Cats: Placed SP Kyle Foster on the 7-day injured list, retroactive to 07/14/2045. |
| Friday, June 30th , 2045 |
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| Springfield Cardinals: RF Jorge Benites was designated for assignment. |
| Sunday, June 11th , 2045 |
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| Bowie Baysox: Placed SS Francisco Viera on the 7-day injured list, retroactive to 06/08/2045. |
| Harrisburg Senators: Activated RP John Hattenhauer from the injured list. |
| Harrisburg Senators: Placed SP Manny Arguelles on the 7-day injured list, retroactive to 06/08/2045. |
| Harrisburg Senators: Placed LF Travis Stanley on the 7-day injured list, retroactive to 06/09/2045. |
| Sunday, June 4th , 2045 |
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| New Hampshire Fisher Cats: Placed CL Dave Kurtz on the active roster. |
| New Hampshire Fisher Cats: Activated CL Dave Kurtz from the injured list. |
| New Hampshire Fisher Cats: Placed C Takanibu Kaneshiro on the active roster. |
| New Hampshire Fisher Cats: Activated C Takanibu Kaneshiro from the injured list. |
| New Hampshire Fisher Cats: Placed 2B Tony Rosas on the 7-day injured list, retroactive to 06/02/2045. |
| Sunday, May 28th , 2045 |
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| Birmingham Barons: Placed CF Brad Boals on the 7-day injured list, retroactive to 05/26/2045. |
| Sunday, May 21st , 2045 |
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| New Hampshire Fisher Cats: Placed LF Sumiki Okuhara on the active roster. |
| New Hampshire Fisher Cats: Activated LF Sumiki Okuhara from the injured list. |
| Sunday, May 7th , 2045 |
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| New Hampshire Fisher Cats: Placed LF Sumiki Okuhara on the 7-day injured list, retroactive to 05/04/2045. |
| Sunday, April 30th , 2045 |
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| Colorado (EL) Rockies: Placed RP Dustin Deemer on the 7-day injured list, retroactive to 04/27/2045. |
| Sunday, April 23rd , 2045 |
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| New Hampshire Fisher Cats: Placed C Takanibu Kaneshiro on the 7-day injured list, retroactive to 04/22/2045. |
| Sunday, April 9th , 2045 |
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| Birmingham Barons: Released 2B Luwen Storm. |
| Birmingham Barons: Released RF Felix Santana. |
| Birmingham Barons: Released RF Sergio Corona. |
| Birmingham Barons: Released RF Victor Lema. |
| Birmingham Barons: Released LF Brian Dickeson. |
| Saturday, April 8th , 2045 |
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| Corpus Christi Hooks: Signed Manager Anthony Lepre. |
| Friday, March 31st , 2045 |
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| New Hampshire Fisher Cats: Appointed Chris Sale as Pitching Coach. |
| New Hampshire Fisher Cats: Appointed Max Meany as Manager. |
| Sunday, February 19th , 2045 |
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| Jackson Generals: Manager Adam Watkins signed as %job_title2 in Jackson. |
| Jackson Generals: Signed Manager Adam Watkins. |
| Wednesday, February 15th , 2045 |
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| Bowie Baysox: Signed Manager Brett Phillips. |
