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| Thursday, December 27th , 2046 |
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| Altoona Curve: Signed Manager Mason Kukowski. |
| Monday, December 17th , 2046 |
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| New Hampshire Fisher Cats: Signed Manager Stu Cole to a 5-year contract extension. |
| Saturday, November 24th , 2046 |
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| Chattanooga Lookouts: RP Luis Sanchez becomes a free-agent. |
| Sunday, November 18th , 2046 |
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| Montgomery Biscuits: Signed Manager Lesley Sammet. |
| Friday, November 2nd , 2046 |
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| Tulsa Drillers: SS Tony Reyna retired from professional baseball. |
| RP Josh Palmer retired from professional baseball. |
| SP Justin Evans retired from professional baseball. |
| RP Andy Alleyne retired from professional baseball. |
| 2B Kentaro Fujii retired from professional baseball. |
| 1B Michael Tuttle retired from professional baseball. |
| CL Nelson Quintanilla retired from professional baseball. |
| RP Orlando Mendoza retired from professional baseball. |
| LF Billy Valadez retired from professional baseball. |
| RP Jonathan Jacquez retired from professional baseball. |
| Bowie Baysox: RF Jose Bethancourt retired from professional baseball. |
| RF Sergio Corona retired from professional baseball. |
| SP Luis Marmolejos retired from professional baseball. |
| Bowie Baysox: RF David Best retired from professional baseball. |
| RP Benjamin Pater retired from professional baseball. |
| Birmingham Barons: 3B Bobby Campbell retired from professional baseball. |
| C D.J. Martinez retired from professional baseball. |
| Birmingham Barons: LF Chris Ackerson retired from professional baseball. |
| RP Jeremy Dobrowolski retired from professional baseball. |
| RP Nate Earnshaw retired from professional baseball. |
| Bowie Baysox: LF Matt Foster retired from professional baseball. |
| LF Troy Hodge retired from professional baseball. |
| 1B Casey Stripling retired from professional baseball. |
| Bowie Baysox: LF Ronnie Cummings retired from professional baseball. |
| RP Josh Harriston retired from professional baseball. |
| LF Dave Ehrlich retired from professional baseball. |
| C Hector Nunez retired from professional baseball. |
| Arkansas Travelers: Hitting Coach Juan Carlos Oviedo retires. |
| San Jose Giants: Pitching Coach Ian Snell retires. |
| Manager Drew Saylor retires. |
| Manager Tim Olson retires. |
| Manager Jorge Piedra retires. |
| Birmingham Barons: Pitching Coach Matt Garza leaves the team, his contract was not renewed |
| Northwest Arkansas Naturals: Hitting Coach Aaron Easterling leaves the team, his contract was not renewed |
| Arkansas Travelers: Pitching Coach Kyle Godfrey leaves the team, his contract was not renewed |
| Jacksonville Suns: Hitting Coach Ed Pedroza leaves the team, his contract was not renewed |
| Harrisburg Senators: Manager Hichori Toyama leaves the team, his contract was not renewed |
| San Antonio Missions: Hitting Coach Jose Yadriel Rolon leaves the team, his contract was not renewed |
| San Jose Giants: Hitting Coach Ramon Flores leaves the team, his contract was not renewed |
| Tuesday, October 30th , 2046 |
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| Colorado (EL) Rockies: SP Carlos Delgado retired from professional baseball. |
| Colorado (EL) Rockies: SP Corey Dalton retired from professional baseball. |
| San Antonio Missions: C Yusuke Nakamura retired from professional baseball. |
| Jackson Generals: SS Tony de Lara retired from professional baseball. |
| Colorado (EL) Rockies: RF Bodil Hardenberg retired from professional baseball. |
| Bowie Baysox: LF Ben Antal retired from professional baseball. |
| Bowie Baysox: C Angel Lescano retired from professional baseball. |
| Altoona Curve: LF Jesse Henly retired from professional baseball. |
| Mississippi Braves: 1B Luis Revilla retired from professional baseball. |
| Jackson Generals: RP Kenzaburo Yoneyama retired from professional baseball. |
| Altoona Curve: C Bahiyy al Din bin Mamdouh retired from professional baseball. |
| Bowie Baysox: RP Wil Martinez retired from professional baseball. |
| Tulsa Drillers: Hitting Coach Drew Henson retires. |
| Biloxi Shuckers: Pitching Coach Tim Greenspan retires. |
| Saturday, September 22nd , 2046 |
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| New Hampshire Fisher Cats: Placed SP Ron Kehoe on the 7-day injured list, retroactive to 09/21/2046. |
| Sunday, August 26th , 2046 |
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| New Hampshire Fisher Cats: Placed 2B Tony Rosas on the 7-day injured list, retroactive to 08/23/2046. |
| Sunday, July 29th , 2046 |
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| New Hampshire Fisher Cats: Placed SP Jeremy Thomsen on the active roster. |
| New Hampshire Fisher Cats: Activated SP Jeremy Thomsen from the injured list. |
| Sunday, July 22nd , 2046 |
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| New Hampshire Fisher Cats: Placed SP Jeremy Thomsen on the 7-day injured list, retroactive to 07/21/2046. |
| Tuesday, July 17th , 2046 |
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| Corpus Christi Hooks: Signed -name %name to a %number-year contract extension. |
| Sunday, July 1st , 2046 |
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| New Hampshire Fisher Cats: Placed LF Tso-lin Fen on the 7-day injured list, retroactive to 06/30/2046. |
| Sunday, June 3rd , 2046 |
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| New Hampshire Fisher Cats: Placed 2B John Michener on the 7-day injured list, retroactive to 05/31/2046. |
| New Hampshire Fisher Cats: Placed 2B Tony Rosas on the active roster. |
| New Hampshire Fisher Cats: Activated 2B Tony Rosas from the injured list. |
| Monday, May 28th , 2046 |
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| Tulsa Drillers: SP Gyu-hyun Kim was designated for assignment. |
| Sunday, May 6th , 2046 |
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| New Hampshire Fisher Cats: Placed 2B Tony Rosas on the 7-day injured list, retroactive to 05/05/2046. |
| Sunday, April 1st , 2046 |
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| Colorado (EL) Rockies: Placed SP Benito Vargas on the 7-day injured list, retroactive to 03/29/2046. |
| Friday, March 30th , 2046 |
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| New Hampshire Fisher Cats: Placed SP Ron Kehoe on the 7-day injured list, retroactive to 03/27/2046. |
| Tuesday, January 2nd , 2046 |
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| Columbia Fireflies: Signed Manager Matt Tomshaw. |
