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| Thursday, December 10th , 2048 |
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| Norfolk Tides: Signed Manager Zelasko Pye. |
| Saturday, December 5th , 2048 |
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| Louisville Bats: Fired Pitching Coach Noah Syndergaard. |
| Friday, December 4th , 2048 |
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| Nashville Sounds: Signed -name %name to a %number-year contract extension. |
| Wednesday, December 2nd , 2048 |
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| Louisville Bats: Fired Manager Aaron Nola. |
| Louisville Bats: Signed Manager Vincent Poopwell. |
| Tuesday, December 1st , 2048 |
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| Reno Aces: Signed Manager Joe Hincks. |
| Thursday, November 26th , 2048 |
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| Norfolk Tides: LF Ernie Weathersbee becomes a free-agent. |
| Durham Bulls: RP Alec Murphy becomes a free-agent. |
| Columbus Clippers: C Jim Keefe becomes a free-agent. |
| Omaha Storm Chasers: SP Dennis Holifield becomes a free-agent. |
| Omaha Storm Chasers: C Sam Britt becomes a free-agent. |
| Rochester Red Wings: RP Matt Walton becomes a free-agent. |
| Rochester Red Wings: RP Mark Case becomes a free-agent. |
| Salt Lake Bees: RP Joe Beam becomes a free-agent. |
| Salt Lake Bees: RP George Rosario becomes a free-agent. |
| Nashville Sounds: 1B Ryan Kinkead becomes a free-agent. |
| Fresno Grizzlies: RP Arturo Vargas becomes a free-agent. |
| New Orleans Zephyrs: SP Mike Powell becomes a free-agent. |
| Iowa Cubs: LF Tim Hone becomes a free-agent. |
| Louisville Bats: SP Sam Alexander becomes a free-agent. |
| Louisville Bats: LF Satoru Handa becomes a free-agent. |
| Indianapolis Indians: CF Luis Ramos becomes a free-agent. |
| Reno Aces: SP Joe Butler becomes a free-agent. |
| Reno Aces: RP Nick Burcham becomes a free-agent. |
| Colorado Springs Sky Sox: SP Trey Price becomes a free-agent. |
| Colorado Springs Sky Sox: SP Cooper Bate becomes a free-agent. |
| Colorado Springs Sky Sox: RP Victor Castillo becomes a free-agent. |
| Thursday, November 19th , 2048 |
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| Buffalo Bisons: Placed 1B Alex Ramos on the active roster. |
| Buffalo Bisons: Activated 1B Alex Ramos from the injured list. |
| Buffalo Bisons: Signed Hitting Coach Gordie Downie to a 5-year contract extension. |
| Buffalo Bisons: Signed Pitching Coach Lucas Giolito to a 5-year contract extension. |
| Wednesday, November 4th , 2048 |
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| Columbus Clippers: LF Tony Ponce retired from professional baseball. |
| Norfolk Tides: RP Dou-guan Ti retired from professional baseball. |
| Albuquerque Isotopes: SP Humberto Gutierrez retired from professional baseball. |
| Norfolk Tides: C Andrew Korman retired from professional baseball. |
| Norfolk Tides: SP Taylor Sightler retired from professional baseball. |
| Louisville Bats: 1B Eric Sullivan retired from professional baseball. |
| Norfolk Tides: RP Roger Warren retired from professional baseball. |
| Norfolk Tides: RP Pat Dantzler retired from professional baseball. |
| Scranton WB RailRiders: Pitching Coach Keith Watson leaves the team, his contract was not renewed |
| Omaha Storm Chasers: Pitching Coach Ricardo Sanchez leaves the team, his contract was not renewed |
| Tacoma Rainiers: Pitching Coach Ryan Charles leaves the team, his contract was not renewed |
| Lehigh Valley IronPigs: Pitching Coach Turner Larkins leaves the team, his contract was not renewed |
| Reno Aces: Manager Jesse Clark leaves the team, his contract was not renewed |
| Oklahoma City Dodgers: Pitching Coach Kumar Rocker leaves the team, his contract was not renewed |
| Saturday, October 31st , 2048 |
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| Gwinnett Braves: RP Jonathan Ballejos retired from professional baseball. |
| Las Vegas 51s: SS Alex Vasquez retired from professional baseball. |
| Louisville Bats: 2B Colin Lord retired from professional baseball. |
| Buffalo Bisons: SP Timo Lantinga retired from professional baseball. |
| Albuquerque Isotopes: SP Jon Turman retired from professional baseball. |
| Reno Aces: 2B Sam Dowdy retired from professional baseball. |
| Oklahoma City Dodgers: SP Tyler Scherer retired from professional baseball. |
| Las Vegas 51s: 3B Roger Renteria retired from professional baseball. |
| Norfolk Tides: SP Ryan Kotter retired from professional baseball. |
| Gwinnett Braves: SP David Krampe retired from professional baseball. |
| Las Vegas 51s: 2B Nick Rang retired from professional baseball. |
| Albuquerque Isotopes: RP Niclas Boman retired from professional baseball. |
| Omaha Storm Chasers: RP Francisco de la Torre retired from professional baseball. |
| Indianapolis Indians: Hitting Coach Roger Kieschnick retires. |
| Albuquerque Isotopes: Hitting Coach Eddy Rodriguez retires. |
| Memphis Redbirds: Hitting Coach Rafael Lopez retires. |
| Norfolk Tides: Manager Daniel McCutchen retires. |
| Monday, October 26th , 2048 |
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| Buffalo Bisons: Placed 1B Alex Ramos on the 7-day injured list, retroactive to 10/25/2048. |
| Tuesday, September 8th , 2048 |
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| Buffalo Bisons: Placed 1B Alex Ramos on the active roster. |
| Buffalo Bisons: Activated 1B Alex Ramos from the injured list. |
| Buffalo Bisons: Placed DH Michel Martineau on the active roster. |
| Buffalo Bisons: Activated DH Michel Martineau from the injured list. |
| Tuesday, September 1st , 2048 |
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| Buffalo Bisons: Placed DH Michel Martineau on the 7-day injured list, retroactive to 08/31/2048. |
| Buffalo Bisons: Placed SS Leo Mair on the 7-day injured list, retroactive to 08/31/2048. |
| Friday, August 21st , 2048 |
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| Buffalo Bisons: Placed 1B Alex Ramos on the 7-day injured list, retroactive to 08/18/2048. |
| Monday, August 17th , 2048 |
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| Columbus Clippers: RP Ryan Southerland was designated for assignment. |
| Friday, August 14th , 2048 |
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| Columbus Clippers: DH Danny Dunham was designated for assignment. |
| Monday, August 10th , 2048 |
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| Lehigh Valley IronPigs: SP William-Floyd Goof was designated for assignment. |
| Friday, August 7th , 2048 |
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| Buffalo Bisons: Placed RP Andres Lozano on the active roster. |
| Buffalo Bisons: Activated RP Andres Lozano from the injured list. |
| Monday, August 3rd , 2048 |
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| Iowa Cubs: SP Brock Lewis was designated for assignment. |
| Sunday, July 26th , 2048 |
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| Buffalo Bisons: Placed SP Gabe Nalley on the active roster. |
| Buffalo Bisons: Activated SP Gabe Nalley from the injured list. |
| Buffalo Bisons: Placed 1B Alex Ramos on the active roster. |
| Buffalo Bisons: Activated 1B Alex Ramos from the injured list. |
| Sunday, July 19th , 2048 |
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| Buffalo Bisons: Placed 1B Alex Ramos on the 7-day injured list, retroactive to 07/16/2048. |
| Friday, June 5th , 2048 |
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| Columbus Clippers: C Justin Ganey was designated for assignment. |
| Friday, May 22nd , 2048 |
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| Columbus Clippers: C Hiroshige Yamada was designated for assignment. |
| Sunday, April 12th , 2048 |
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| Buffalo Bisons: Signed Manager Andrew Yerzy to a 5-year contract extension. |
| Wednesday, April 1st , 2048 |
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| Iowa Cubs: Placed SP Matt Tomlinson on the 7-day injured list, retroactive to 03/29/2048. |
| Monday, February 3rd , 2048 |
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| Reno Aces: Signed Manager Jesse Clark. |
| Monday, January 13th , 2048 |
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| Fresno Grizzlies: Signed Manager Darryl Kennedy. |
