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| Tuesday, December 5th , 2045 |
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| Bristol Pirates: Signed Manager J.J. Barajas. |
| Wednesday, November 29th , 2045 |
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| Orem Owlz: Signed Manager Reggie Wilson. |
| Saturday, November 25th , 2045 |
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| Bluefield Blue Jays: Placed SP Bobby Enright on the active roster. |
| Bluefield Blue Jays: Activated SP Bobby Enright from the injured list. |
| Bluefield Blue Jays: Placed SP Philip Sonnichsen on the active roster. |
| Bluefield Blue Jays: Activated SP Philip Sonnichsen from the injured list. |
| Bluefield Blue Jays: Placed RP Aaron Meiggs on the active roster. |
| Bluefield Blue Jays: Activated RP Aaron Meiggs from the injured list. |
| Kingsport Mets: Placed RP Keith Noftall on the 7-day injured list, retroactive to 11/22/2045. |
| Pulaski Yankees: Placed C Matt Bindel on the 7-day injured list, retroactive to 11/22/2045. |
| Detroit (APP) Tigers: Activated RP Josh Sinclair from the injured list. |
| Elizabethton Twins: Placed SP Edwin Sanchez on the 7-day injured list, retroactive to 11/22/2045. |
| Elizabethton Twins: Placed SS Alex Belton on the 7-day injured list, retroactive to 11/22/2045. |
| Burlington Royals: Placed RP Kolenka Leschenya on the 7-day injured list, retroactive to 11/22/2045. |
| Burlington Royals: Placed CL Nam Phong on the 7-day injured list, retroactive to 11/22/2045. |
| Burlington Royals: Placed RP Justin Potts on the 7-day injured list, retroactive to 11/22/2045. |
| Saturday, November 4th , 2045 |
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| Great Falls Voyagers: Pitching Coach Wade LeBlanc retires. |
| Burlington Royals: Pitching Coach Alexandro Delgado leaves the team, his contract was not renewed |
| Seattle (APP) Mariners: Pitching Coach Butch Cortez leaves the team, his contract was not renewed |
| Philadelphia (APP) Phillies: Hitting Coach Danny Burawa leaves the team, his contract was not renewed |
| Philadelphia (APP) Phillies: Pitching Coach Chris Hatcher leaves the team, his contract was not renewed |
| Washington (APP) Nationals: Hitting Coach Ryan Tella leaves the team, his contract was not renewed |
| Johnson City Cardinals: Hitting Coach Ben Young leaves the team, his contract was not renewed |
| Missoula Osprey: Hitting Coach Dreily Guerrero leaves the team, his contract was not renewed |
| Ogden Raptors: Pitching Coach Robert Fish leaves the team, his contract was not renewed |
| Friday, October 13th , 2045 |
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| Seattle (APP) Mariners: Signed -name %name to a %number-year contract extension. |
| Sunday, September 10th , 2045 |
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| Great Falls Voyagers: Placed SS Alfie Bungledorf on the active roster. |
| Great Falls Voyagers: Activated SS Alfie Bungledorf from the injured list. |
| Friday, September 1st , 2045 |
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| Great Falls Voyagers: Placed SS Alfie Bungledorf on the 7-day injured list, retroactive to 08/29/2045. |
| Sunday, July 30th , 2045 |
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| Bluefield Blue Jays: Placed CL Nick Burnstein on the 7-day injured list, retroactive to 07/27/2045. |
| Sunday, July 16th , 2045 |
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| Bluefield Blue Jays: Placed SP Philip Sonnichsen on the 7-day injured list, retroactive to 07/13/2045. |
| Monday, June 26th , 2045 |
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| Billings Mustangs: Fired Pitching Coach Jason Wilhite. |
| Sunday, June 18th , 2045 |
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| Bluefield Blue Jays: Placed SP Bobby Enright on the 7-day injured list, retroactive to 06/15/2045. |
| Sunday, June 11th , 2045 |
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| Baltimore (APP) Orioles: Placed 2B Danny Baeza on the 7-day injured list, retroactive to 06/10/2045. |
| Baltimore (APP) Orioles: Placed SS Honório Szenes on the 7-day injured list, retroactive to 06/08/2045. |
| Sunday, June 4th , 2045 |
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| Bluefield Blue Jays: Placed 2B Norm Mercer on the active roster. |
| Bluefield Blue Jays: Activated 2B Norm Mercer from the injured list. |
| Bluefield Blue Jays: Placed RF Frank Nelson on the active roster. |
| Bluefield Blue Jays: Activated RF Frank Nelson from the injured list. |
| Monday, May 29th , 2045 |
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| Greeneville Astros: Signed Manager T.J. Weir. |
| Monday, May 22nd , 2045 |
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| Baltimore (APP) Orioles: Signed Manager Alexis De Los Santos. |
| Sunday, April 9th , 2045 |
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| Great Falls Voyagers: Released C Jesse Loomis. |
| Great Falls Voyagers: Released C Juan Tovar. |
| Great Falls Voyagers: Released LF Kevin Larsen. |
| Great Falls Voyagers: Released LF D.J. McManigle. |
| Great Falls Voyagers: Released RF John Myers. |
| Great Falls Voyagers: Released LF Jake Savell. |
| Saturday, April 8th , 2045 |
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| Greeneville Astros: Signed Manager Mark Carver. |
| Wednesday, March 15th , 2045 |
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| Burlington Royals: Signed Manager Henry Villar. |
| Sunday, February 19th , 2045 |
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| Seattle (APP) Mariners: Signed Manager Greg Thorpe. |
